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Ninja Nerds!
In this metabolism lecture, Professor Zach Murphy dives into the complex yet essential topic of Cholesterol Metabolism, guiding you through the synthesis, transport, regulation, and physiological roles of cholesterol in the human body. This lecture highlights how cholesterol functions as a structural lipid, a precursor for hormones, bile acids, and vitamin D, and a key player in cardiovascular health.

We begin with the biosynthesis of cholesterol, tracing the conversion of acetyl-CoA into mevalonate via HMG-CoA reductase, the rate-limiting and highly regulated step. You’ll learn how this enzyme is modulated by insulin, glucagon, and intracellular cholesterol levels, as well as how statins pharmacologically target this pathway.

The lecture continues with an in-depth review of lipoprotein transport, emphasizing the roles of chylomicrons, VLDL, LDL, and HDL in distributing cholesterol to and from peripheral tissues. We explore receptor-mediated uptake via LDL receptors, reverse cholesterol transport by HDL, and the clinical implications of dyslipidemia and atherosclerosis.

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